PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4098)
Related Products (4098)
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PROTAC Linkers Isoform Comparison
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Ph-PEG3
0 ImagesCat. No.: HY-W096158CAS No.: 7204-16-2
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N-Ethylpropionamide-PEG1-Br
0 ImagesCat. No.: HY-134732CAS No.: 1539080-27-7
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Mal-PEG10-acid
0 ImagesCat. No.: HY-138723CAS No.: 3034751-36-2
![7-[(2-Aminoethyl)carbamoyl]heptanoic acid](https://file.medchemexpress.com/product_pic/hy-182982.gif "Click to View 7-[(2-Aminoethyl)carbamoyl]heptanoic acid Product Detail")
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Boc-NH-PEG7-acid
0 ImagesCat. No.: HY-140469CAS No.: 2055044-68-1
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Azido-PEG11-acid
0 ImagesCat. No.: HY-133317CAS No.: 2769916-01-8Synonyms: N3-PEG11-CH2CH2COOHAzido-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG11-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(m-PEG4)-N'-(PEG4-NHS ester)-Cy5
0 ImagesCat. No.: HY-141046CAS No.: 2107273-30-1
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Acid-PEG5-TEMPO
0 ImagesCat. No.: HY-140512CAS No.: 2055040-79-2
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Propargyl-PEG3-Boc
0 ImagesCat. No.: HY-140027CAS No.: 1374658-84-0
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Br-PEG9-C2-NHBoc
0 ImagesCat. No.: HY-138384CAS No.: 2688072-19-5
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3-Aminophenol-PEG4-methyl
0 ImagesCat. No.: HY-134742CAS No.: 1429340-32-8
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Ald-Ph-PEG12-TFP ester
0 ImagesCat. No.: HY-140624CAS No.: 3031166-52-3
